The neuroprotective effect on ethanolic extract of A. galanga, P. viscida, various fractions obtained from A. galanga and the bioactive compound isolated from the chloroform fraction of A. galanga improved the
ثبت نشده
چکیده
HISTOPATHOLOGICAL REPORT The brain section of control animals injected with PBS, shows normal configuration and architecture of cells in hippocampus (Figure: 74; a). In Aβ negative control, the hippocampal sections showed degenerated nerve cells and enlarged swollen nuclei as well as spongiform architecture. This swollen and enlargement indicates the presence of diffused plaques which is neurotoxicity of Aβ in the hippocampal cells (Figure: 74; b). The brain sections of standard drug treated animals shows the normal nuclei and architecture of cells (Figure: 74; c). In the drug treated group, DAEA, all the three different doses such as 12.5, 25 and 50mg/kg shown normal cells of hippocampus and cortex without any spongiform cells, indicates the protective effect of DAEA (Figure: d, e, f, I, j, k and l). Even though all the brain samples of DAEA treated animals show the protective effect in all doses, the low dose treated animals brain sections indicated a slight edematous nature of the neuronal architecture
منابع مشابه
Antioxidant capacity and radioprotective properties of the flavonoids galangin and kaempferide isolated from Alpinia galanga L. (Zingiberaceae) against radiation induced cellular DNA damage
Background: Alpinia galanga L. belonging to the family Zingiberaceae is widely grown in the state of Kerala, India. They are effective antioxidant and free radical scavenger under both in vitro and in vivo condition. The efficacy of the isolated flavonoids in conferring protection from radiation induced damages to genomic DNA was studied. Materials and Methods: The bioflavonoids, galangin and k...
متن کاملIsolation of β-Sitosterol Diarabinoside fromRhizomes of Alpinia Galanga
Alpinia galanga is rhizome, generally known as Greater galangal and is selected for isolation of newer constituents accountable for various therapeutic activities. Present study is intended to isolate glycoside from Alpinia galanga rhizomes. Alpinia galanga methanolic extract was column chromatograph and eluted with ethyl acetate-methanol (99:1) to isolate compound β-Sitosterol Diarabinoside. H...
متن کاملAnti-inflammatory activity of ethanolic extract of Alpinia galanga in carrageenan induced pleurisy rats
Background: Alpinia galanga belonging to Zingiberaceae family was traditionally used to treat numerous inflammatory disorders. The rationale behind its use since ages has to be scientifically validated for developing newer therapeutic agents. Aims and Objectives: Anti-inflammatory activity of ethanolic extract of A. galanga in carrageenan induced pleurisy rats. Materials and Methods: This study...
متن کاملBioactivity-guided isolation of ethyl-p-methoxycinnamate, an anti-inflammatory constituent, from Kaempferia galanga L. extracts.
This study evaluated the anti-inflammatory effect of Kaempferia galanga (KG) using an activity-guided approach. KG rhizomes were serially extracted with petroleum ether, chloroform, methanol and water. These extracts (2 g/kg each) were tested for their ability to inhibit carrageenan-induced rat paw edema. The chloroform extract was found to exert the highest inhibition (42.9%) compared to contr...
متن کامل